Severe insomnia from clonidine8/12/2023 ![]() ![]() We present a case of somnambulism associated with the use of clonidine in a patient of ADHD.Ī 7-year-old male patient with a history of ADHD, oppositional defiant disorder and insomnia, presented with hyperactivity, restlessness, distractibility, and inattention causing poor academic performance. Long-term use of intrathecal clonidine in a patient suffering from postoperative pain also complained of vivid dreams and night terror, which subsided with clonidine withdrawal. Somnambulism was reported in a child who received 0.2 mg of clonidine. Few studies have indicated a possible association of clonidine with somnambulism. ![]() Clonidine, an α-2 agonist, is used for psychiatric disorders such as ADHD, substance abuse, insomnias, and parasomnias. Attention deficit hyperactivity disorder (ADHD) is associated with various forms of sleep disorders. © 2022 American Academy of Sleep Medicine.Somnambulism is a relatively common childhood parasomnia, affecting ~25% of children with sleep-related problem. 2022 18(6):1565-1571.Ĭhronic pain clonidine insomnia sedative hypnotic sleep sleep score zopiclone. Clonidine is better than zopiclone for insomnia treatment in chronic pain patients. Further studies comparing clonidine with other insomnia medications will be beneficial.īamgbade OA, Tai-Osagbemi J, Bamgbade DO, et al. A minor adverse effect of dry mouth was commoner with clonidine.Ĭlonidine is significantly better than zopiclone with respect to sleep quality, analgesia, tolerability profile, and patient safety. Adverse effects were commoner with zopiclone, including collapse, fall, confusion, amnesia, mood disorder, hallucination, nightmare, nocturnal restlessness, locomotor dysfunction, nausea and headache. Total sleep duration was better with clonidine than zopiclone ( P =. Total Likert sleep score was better with clonidine than zopiclone ( P =. Overall sleep quality was better with clonidine than zopiclone ( P =. Feeling rested on waking in the morning was better with clonidine than zopiclone ( P =. Time to fall asleep was shorter with clonidine than zopiclone ( P =. Pain score was lower with clonidine than zopiclone ( P =. Of the 160 study participants, 150 (93.8%) completed the study successfully, and their data were analyzed with IBM SPSS Statistics 25 (IBM Corporation, Armonk, NY) using Student's t test, analysis of variance, Pearson chi-square test, and regression analysis. A change in the pain or sleep scores by 2 points was considered significant. Sleep score was measured using the Likert Sleep Scale. Pain was measured using a numeric pain rating scale. Each patient completed the diary for 3 continuous weeks. Each patient used a special validated sleep diary to collect data including pain score, sleep scores, sleep duration, sleep medication dose, and adverse effects. For insomnia treatment, each patient ingested different prescribed doses of zopiclone or clonidine on alternate nights. This prospective observational crossover study included 160 consenting adult patients receiving pain management treatment. The objective of this clinical study was to compare the efficacy and safety of different prescribed doses of zopiclone and clonidine for the management of insomnia in patients with chronic pain. Chronic pain is associated with insomnia. ![]()
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